Non-motor fluctuations (NMF) in people with Parkinson’s disease (PwP) are clinically important yet understudied.

To study NMF in PwP using both the Movement Disorder Society Non-Motor Rating Scale (MDS-NMS) NMF subscale and wearable sensors.

Non-motor fluctuations prevalence in PwP increases with disease duration, but in a pattern different from motor fluctuations. Moreover, NMF can occur in PwP without dyskinesia, and in those with NMF the severity of NMF increases most during years 2–5 after diagnosis.

Characterization of Non‐Motor Fluctuations Using the Movement Disorder Society Non‐Motor Rating Scale – Wamelen – 2022 – Movement Disorders Clinical Practice – Wiley Online Library